Quantitative evaluation of blood brain barrier disruption in cold induced edema.
نویسندگان
چکیده
منابع مشابه
[Quantitative evaluation of blood brain barrier disruption in cold induced edema].
脳 浮腫 は種 々の頭蓋 内疾患 に よ りもた らされ る病態 であ るが,そ の 本態 に関 しては まだ未知 な ところが少 な くないn.脳 浮 腫 の解 明 に多 くの実 験 モデ ルが使 用 され てい るが,脳 凍 結 損傷 モデル は脳 血管壁 を直接 傷 害す る こ とに よ り,血 液脳 関 門(bloodbrainbarrier 以下BBBと 略す)の 障害 が起 こ り,主 に細胞 外間 隙に 水分 お よび血 漿蛋 白が漏 出 して 生 じる脳浮腫 モデ ルで あ る.こ の場 合 のBBBの 障 害の定 量 的測定 は従 来 よ り脳浮 腫の病 態把握 に欠 かせ ない検査 法 と して広 く検 討 されて きた.BBBの 障 害 を測定 す る方 法 と して は Evansblue(EB)の 血管外 漏 出を肉眼的,ま たは蛍 光 顕 微鏡 に よ ...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 1992
ISSN: 0048-0444,1884-0108
DOI: 10.1272/jnms1923.59.62